The U.S. Economic Development Administration mandates that each designated Economic Development District develops and maintains a Comprehensive Economic Development Strategy with the assistance of public involvement. The South Florida Regional Planning Council used the REMI PI+ model to update their previous five-year strategy to better serve their district and its constituents. This update was divided into five main sections (Summary Background, SWOT Analysis, Strategic Action Plan, Evaluation Framework, and Economic Resilience) while also including regional fact sheets for the overall district and each individual county. The REMI model was utilized to analyze the various impacts of specific performance measures outlined in the strategy in terms of business climate and competitiveness, innovation and economic development, talent supply and education, and quality of life and places. The key findings from the South Florida Regional Planning Council’s analysis and several detailed graphs are included in this comprehensive economic development strategy to best illustrate their plans for the district’s future.